The director’s family said that he and his wife, Michele, had died on Sunday. The police said they had found two bodies at the Reiner home in Los Angeles.

Medetomidine, a veterinary sedative, mixed into fentanyl has sent thousands to hospitals, not only for overdose but for life-threatening withdrawal. It is spreading to other cities.

For the second day running, President Volodymyr Zelensky of Ukraine was set to meet in Berlin with Steve Witkoff and Jared Kushner, two key Trump aides.

Falling in love with her inspired the director Rob Reiner to give “When Harry Met Sally…” a new ending. The Reiners went on to work together on movies and political causes.

Plus, the hunt for the gunman in a shooting at Brown University.

José Antonio Kast, who was elected president on Sunday, is the latest conservative to rise to power promising strict law and order measures.

The Milwaukee County judge faces federal charges, but she has maintained her innocence.

Advocates fear damage to labor protections if the Supreme Court upholds the president’s move to control federal agency staffing.

Across the arts, these 10 performers took a leap of faith this year and stuck the landing in a big way.

A program for deafblind children helped 3-year-old Annie Garner, born with poor vision and no ears, learn to communicate. The Trump administration cut the program’s funding over diversity goals.

Sometimes Trump’s unconventional foreign policy just works.

The new chancellor believes the world needs a stronger Germany. He is still navigating how to do it.

Mr. Reiner, who was in “All in the Family,” directed films including “This Is Spinal Tap,” “When Harry Met Sally …,” “The Princess Bride” and “A Few Good Men.”

Two gunmen opened fire at dozens of people who were at a Jewish holiday event. At least 15 people were killed in the attack, and so was one of the shooters, the police said.

The number of artists living in the city has declined after growing sharply between 2004 and 2019. Almost 50 arts venues have closed in the past five years.

A broad measure of investment fell more than 10 percent in November, continuing a recent reversal and signaling the depth of China’s property crisis.

Students sheltered in place in classrooms and basements, waiting for the all clear.

He attributed his rags-to-riches ascent to the freedoms of Hong Kong, and has paid a hefty price for defending them.

Her picture books found models of perseverance and imagination in figures like Emily Dickinson, Georgia O’Keeffe and Benny Goodman.

A former director of the Centers for Disease Control and Prevention and a former chief medical officer of the agency will advise the state on public health issues.

The Air Force refueling tanker was flying without its location transponder activated and could not be detected by air traffic control.

The city has not seen this much snow this early in the season since 2018, the National Weather Service said.